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FLASH GENE

Symbol

RAX

contributors: mct/npt - updated : 03-04-2018

HGNC name	retina and anterior neural fold homeobox
HGNC id	18662

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	6.36 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_013435 3 - 3197 36.8 346 - 1997 9177348

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       lowly Visual eye retina

cells

System Cell Pubmed Species Stage Rna symbol Nervous optic nerve

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	eyes, lens, anterior segment, optic nerve, retina foveal and macular, RPE and choroid

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a highly conserved paired-like homeodomain
	an octopeptide typical of this homeo box gene subfamily
	one OAR domain

HOMOLOGY

interspecies	homolog to rattus Rax
	ortholog to murine Rax

Homologene

FAMILY	paired homeobox family
	bicoid subfamily

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	playing a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation
	essential for vertebrate eye development
	its function is required for the specification and maintenance of retinal progenitor cells
	is also necessary during retinal regeneration
	potentially contributes to phenotype maintenance in the mature retina and pineal gland

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

text	eye development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts with embryonic enhancer locus for photoreceptor OTX2 transcription to transactivate OTX2, mainly in the final cell cycle of retinal progenitors
	LHX2 is a key intrinsic regulator of tanycyte differentiation, sustaining RAX-dependent activation of tanycyte-specific genes while also inhibiting expression of ependymal cell-specific genes

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MCOP3

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS