basic FUNCTION
| acts as a transcriptional repressor by interacting with class I histone deacetylases and the G9a histone methyltransferas |
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acts as a novel epigenetic regulator of SMC phenotypic plasticity by suppressing differentiation and maintaining the proliferative potential of vascular SMCs |
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acts as a novel epigenetic regulator of smooth muscle cells (SMC) phenotypic plasticity by suppressing differentiation and maintaining the proliferative potential of vascular SMCs (Davis 2006) |
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has differential effects in endothelial cells and smooth muscle cells, and may play a role in vascular precursor differentiation and survival by modulating local chromatin-remodeling activity within hematovascular subpopulations during development (Wu 2008) |
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is a factor that is essential for the physiological control of cardiovascular development |
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encodes a nuclear protein that is specific to vascular smooth muscle cells (VSMC), has histone methyl transferase activities, and acts as a transcriptional suppressor of contractile proteins |
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maintains VSMCs in an undifferentiated state during embryonic life, a function most likely required for their proliferation |
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plays a key role in maintaining VSMCs in an undifferentiated stage in order to promote their proliferation and that its loss of activity results in premature differentiation and impaired remodeling of the ductus arteriosus (DA) |
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wild-type PRDM6 reduced dimethylation of H3K9 and increased dimethylation of H4K20, whereas both variant PRDM6 proteins had completely opposite effects |