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FLASH GENE
Symbol PRDM13 contributors: mct - updated : 18-05-2022
HGNC name PR domain containing 13
HGNC id 13998
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one SET domain
  • four zinc finger DNA binding motifs, C2H2 type
    • HOMOLOGY
    Homologene
    FAMILY PR-domain protein family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcriptional regulator previously implicated in neuronal specification in the retina and spinal cord
  • regulates development of a subset of amacrine cells, which newly defines an amacrine subtype to negatively modulate visual sensitivities
  • is required for Ebf3+ amacrine cell formation in the retina
  • requirement of PRDM13 for Purkinje cell differentiation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDIDHH , MCDR1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Prdm13 knockout mice display dorso-ventral cell specification defects in the fetal neural tube and die neonatally of unknown reasons