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FLASH GENE
Symbol PRRX1 contributors: mct - updated : 22-08-2012
HGNC name paired related homeobox 1
HGNC id 9142
ANIMAL & CELL MODELS
  • loss of function mutation in the mouse Pmx1 gene
  • Homozygous for the mutant allele died soon after birth and exhibited defects of skeletogenesis
  • mice lacking Prrx1 die postnatally and have impaired formation of osteogenic and chondrogenic progenitors, resulting in defective skeletogenesis