basic FUNCTION
| transcription coactivator, enhancing the DNA-binding activity of serum response factor |
|
regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types |
|
required for pulmonary vascular development |
|
PRRX1, and PRRX2, encode transcription factors critical for orofacial development and are critical for mesenchymal-epithelial signaling during tooth morphogenesis |
|
PRRX1 and PRRX2 cooperatively regulate the morphogenesis of the medial region of the mandibular process |
|
have a critical role in limb bud formation and skeletal patterning |
|
obligate mediator of TNF inhibition of SP7 and differentiation of osteoblasts progenitors |
|
involvement of PRRX1 and PRRX2 in organogenesis of tissue originating from the ectoderm other than the mesoderm |
|
is an inhibitor of adipogenesis that may impact adipose tissue function in obesity |
|
restrains adipogenesis by regulating expression of TGFB1 ligands and thereby activating TGFB1 signaling |
|
impacts adipose tissue formation and function in the context of obesity and other metabolic diseases |
|
plays an important role as a key switch for neural cell lineage determination and the maintenance of the self-renewal of adult neural stem cells (NSCs) at several stages in the adult brain |