Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

PLCE1

contributors: mct/npt - updated : 28-12-2020

HGNC name	phospholipase C, epsilon 1
HGNC id	17175

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SRN3 , NPHS3

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   lower in hepatocellular carcinoma (HCC) cell lines than normal liver epithelial cells and significantly associated with poorer overall survival tumoral     --low   in 42p100 of colorectal cancer tissues compared with pair-matched normal tissues

Susceptibility

to gastric adenocarcinoma and esophageal squamous cell carcinoma to dengue shock syndrome

Variant & Polymorphism other	variant assoiciated to risk of gastric adenocarcinoma and esophageal squamous cell carcinoma
	variant increasing susceptibility for dengue shock syndrome

Candidate gene
Marker	may function as a promising biomarker for HCC prognosis
Therapy target
	System Type Disorder Pubmed cancer digestive oesophagus targeting PLCE1 and its downstream molecules could be effective therapies for esophageal cancer

ANIMAL & CELL MODELS