basic FUNCTION
| initiating a cascade of intracellular responses that result in cell growth and differentiation and gene expression |
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required for cell growth |
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has an oncogenic role in skin and intestinal carcinogenesis through inflammation signaling pathways, and in head and neck squamous cell carcinoma progression by binding Ras family small GTPases |
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crucial podocyte protein, highly expressed in embryonic and mature glomeruli, which catalyzes the hydrolysis of phosphatidylinositol-4,5-bispohosphate and generates the second messengers inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG) (Machuca 2009) |
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might regulate cell growth, differentiation, apoptosis and angiogenesis |
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may be involved in the development of sporadic colorectal cancer through its inhibitory effect on cell proliferation |
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essential roles of PLCE1 in esophageal carcinoma cells |
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PLCE1 also plays a role in the proliferation and differentiation of podocytes, regardless of the presence of NCK2 |
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