| basic FUNCTION
| is deemed responsible for digesting the mitochondrial targeting sequence (MTS) of proteins imported across the inner mitochondrial membrane |
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genetic variation in PITRM1 may potentially contribute to mitochondrial dysfunctions  |
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zinc metalloendopeptidase that has been implicated in Alzheimer disease and mitochondrial peptide degradation |
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is responsible for the degradation of presequences and other unstructured peptides including the amyloid-beta peptide, whose accumulation may have deleterious effects on mitochondrial function |
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mitochondrial matrix enzyme, which digests oligopeptides, including the mitochondrial targeting sequences that are cleaved from proteins imported across the inner mitochondrial membrane and the mitochondrial fraction of amyloid beta (APP) |
