Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PGLYRP1 contributors: mct - updated : 09-01-2015
HGNC name peptidoglycan recognition protein 1
HGNC id 8904
Location 19q13.32      Physical location : 46.522.411 - 46.526.556
Synonym name
  • peptidoglycan recognition protein
  • TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein)
  • Synonym symbol(s) PGRP, TAG7, PGRP-S, TNFSF3L, PGLYRP, PGRPS, MGC126894, MGC126896
    DNA
    TYPE functioning gene
    STRUCTURE 3.88 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 972 - 196 - 2004 15572450
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  lowly
     liver   lowly
    Lymphoid/Immunespleen   lowly
     thymus   lowly
    Respiratorylung   lowly
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow    Mus musculus
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Respiratoryalveolar macrophage Mus musculus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal signal peptide
  • extracellular PGRP domains III, II, and I
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • N-acetylmuramoyl-L-alanine amidase 2 family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text secreted protein
    basic FUNCTION
  • peptidoglycan receptor activity involved in innate immune response to Gram-positive bacteria
  • plays an important role both in antibacterial defenses and several inflammatory diseases
  • binding to and inhibiting the growth of S.aureus and E.coli
  • mediates antibacterial host defense
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text innate immune response
    PATHWAY
    metabolism
    signaling
    a component
  • PGLYRP1 forms with HSPA4 a stable complex with cytotoxic and antitumor activity
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • formation of PGLYRP1-S100A4 complex had virtually no effect on the role of S100A4 in the regulation of intracellular Ca2+ metabolism
  • HSPBP1 incapacitates the HSPA4-PGLYRP1 complex
  • cell & other
  • binding to gram-positive bacteria, B. subtilis and M. luteus, with high affinity
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • chimeric mice lacking Pglyrp1 on hematopoietic cells, not structural cells, showed a reduction in house dust mite (HDM)-induced eosinophilic and lymphocytic airway inflammation