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FLASH GENE
Symbol PANX2 contributors: mct/npt - updated : 06-03-2010
HGNC name pannexin 2
HGNC id 8600
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • pannexin family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • predominantely detected in the cytoplasm in vesicle-like patterns but not at the plasma membrane (Lai 2009)
  • localizing to Golgi and endoplasmic reticulum membranes
    • basic FUNCTION
  • contribute to the electrical and metabolic coupling, or to signaling between retinal neurons via the secondary messengers (Dvoriantchikova 2006)
  • like connexins, may play an important role in hearing (Wang 2009)
  • PANX2 protein expression plays a role in regulating the timing of neuronal differentiation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • strongly interacts with the core and high-mannose species of PANX1 but not with PANX3 (Penuela 2009)
  • physically interacts with PANX1 to reduce current amplitude
    • cell & other
    REGULATION
    Other regulated by glycosylation (regulates pannexin intermixing and cellular localization) (Penuela 2009)
    endogenous post-translational regulation, specific to early neural progenitor cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrant expression during gliomagenesis (Lai 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS