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FLASH GENE
Symbol DMBX1 contributors: mct - updated : 26-04-2017
HGNC name diencephalon/mesencephalon homeobox 1
HGNC id 19026
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus LOC313512
homolog to murine Dmbx1
Homologene
FAMILY bicoid subfamily of homeodomain containing transcription factor
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • playing a role in brain and sense organ development
  • involved in the development of the neural network for the signaling, being essential for various actions of agouti-related protein (AGRP)
  • plays a role in normal regulation of energy homeostasis and behavior
  • brain-specific homeodomain transcription factor expressed primarily during embryogenesis
  • in the adult lateral parabrachial nucleus (LPB), is required for the long-lasting orexigenic effect of AGRP via the neural circuitry involving calcitonin gene-related peptide neurons
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • VSX2 gene expression requires active FGF signaling and this in turn suppresses DMBX1 expression and maintains cells in an undifferentiated, proliferative retinal progenitor cells (RPCs) state
  • antagonistic relationship between VSX2 and DMBX1 to control retinal progenitor cells (RPCs) proliferation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS