Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

DMBX1

contributors: mct - updated : 26-04-2017

HGNC name	diencephalon/mesencephalon homeobox 1
HGNC id	19026

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p33      Physical location : 46.972.667 - 46.979.884
Synonym name	orthodenticle homolog 3 (Drosophila)
	paired-like homeobox protein DMBX1-like
	homeoprotein MBX
Synonym symbol(s)	HGNC19026, MBX, PAXB, OTX3

DNA

TYPE	anonymous DNA segment
SPECIAL FEATURE	arranged in tandem
STRUCTURE	24.39 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_147192 4 - 2896 NP_671725 41 382 - 2002 12142024 NM_172225 4 - 2881 NP_757379 40 377 - 2002 12142024

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to rattus LOC313512
	homolog to murine Dmbx1

Homologene

FAMILY

bicoid subfamily of homeodomain containing transcription factor

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	playing a role in brain and sense organ development
	involved in the development of the neural network for the signaling, being essential for various actions of agouti-related protein (AGRP)
	plays a role in normal regulation of energy homeostasis and behavior
	brain-specific homeodomain transcription factor expressed primarily during embryogenesis
	in the adult lateral parabrachial nucleus (LPB), is required for the long-lasting orexigenic effect of AGRP via the neural circuitry involving calcitonin gene-related peptide neurons

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein	VSX2 gene expression requires active FGF signaling and this in turn suppresses DMBX1 expression and maintains cells in an undifferentiated, proliferative retinal progenitor cells (RPCs) state
	antagonistic relationship between VSX2 and DMBX1 to control retinal progenitor cells (RPCs) proliferation

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS