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FLASH GENE
Symbol HBZ contributors: - updated : 29-08-2006
HGNC name hemoglobin, zeta
HGNC id 4835
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immune    highly
 spleen   highly
Reproductivefemale systemplacenta  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerthrocyte
Blood/Hematopoieticerythroblast
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text synthesized in the yolk sac of the early embryo
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight helical segments A to H
  • non helical N and C termini
  • non helical linkers
    • conjugated HemoP , Other
    mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies ortholog to murine Hba-x
    homolog to C.elegans R03A10.1
    Homologene
    FAMILY globin family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION transporting oxygen and carbon dioxide between the lung and tissues
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cell to cell transport
    text oxygen transporter
    PATHWAY
    metabolism
    signaling
    a component
  • heterotetramer of two zeta chains and two epsilon chains in early embryonic hemoglobin gower-1
  • heterotetramer of two zeta chains and two gamma chains in hemoglobin portland-1
    • INTERACTION
    DNA
    RNA
    small molecule other,
    heme ferroporphyrin binding O2 and anchored to distal and proximal histidine of the HbA chain, embedded in the pocket between helices E and F
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ATHAL
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS