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FLASH GENE
Symbol HBG2 contributors: mct - updated : 25-04-2013
HGNC name hemoglobin, gamma G
HGNC id 4832
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight helical segments A to H,
  • non helical N and C termini and non helical linkers
    • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • globin family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • transporting oxygen and carbon dioxide between the lung and tissues
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text oxygen transport
    PATHWAY
    metabolism
    signaling
    GATA1/ZFPM1/NuRD Pathway implicated in expression of HBG2
    a component
  • heterodimer alpha gamma forming a heterotetramer alpha2 gamma2 in the fetal hemoglobin, A type
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • alpha chain in fetal hemoglobin
  • KLF1 and KLF2 bind directly to the promoters of the HBE1 and HBG1, HBG2 genes
  • BCL11A expression is activated by KLF1, leading to HBG1, HBG2 repression
    • cell & other
    REGULATION
    Other regulated by IKAROS (involved in the regulation of human globin gene switching)
    NuRD complex is required for ZFPM1-dependent activation of adult-type globin gene expression but is dispensable for gamma-globin silencing
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS