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FLASH GENE

Symbol

HBG2

contributors: mct - updated : 25-04-2013

HGNC name	hemoglobin, gamma G
HGNC id	4832

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	member of the HB-NA cluster (see HB-NA@)
STRUCTURE	1.59 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

text structure

high level of copy number instability in sperm of older men

MAPPING

cloned

Y

linked

N

status

confirmed

Map	see HB-NA@
Authors	Keys (2008)

regionally located

5'-HBE1, HBG2, HBG1, HBD, HBB-3'

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000184 3 - 583 NP_000175 16 147 - 2007 17462922

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Endocrine neuroendocrine pituitary     highly Hearing/Equilibrium ear       highly Lymphoid/Immune spleen       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic erthrocyte Blood/Hematopoietic erythroblast

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, perinatal, pregnancy

Text	silenced around the time of birth

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	eight helical segments A to H,
	non helical N and C termini and non helical linkers

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY

globin family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION

transporting oxygen and carbon dioxide between the lung and tissues

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	oxygen transport

PATHWAY

metabolism

signaling

GATA1/ZFPM1/NuRD Pathway implicated in expression of HBG2

a component

heterodimer alpha gamma forming a heterotetramer alpha2 gamma2 in the fetal hemoglobin, A type

INTERACTION

DNA

RNA

small molecule

protein	alpha chain in fetal hemoglobin
	KLF1 and KLF2 bind directly to the promoters of the HBE1 and HBG1, HBG2 genes
	BCL11A expression is activated by KLF1, leading to HBG1, HBG2 repression

cell & other

REGULATION

Other	regulated by IKAROS (involved in the regulation of human globin gene switching)
	NuRD complex is required for ZFPM1-dependent activation of adult-type globin gene expression but is dispensable for gamma-globin silencing

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS