| basic FUNCTION
| negative regulator of cell signaling in T cells |
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limiting antiapoptotic signal |
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playing a key role in hematopoiesis |
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may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation via its PTPase activity |
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downregulating IL-3 inducing tyrosine phosphorylation and mitogenesis |
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involved in the regulation of glucose homeostasis through modulation of insulin signaling in liver and muscle as well as hepatic insulin clearance |
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playing a role with PTPRK in the regulation, maintenance, and restitution of cell adhesions in a complex epithelial organ such as the pancreas |
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key negative regulator of TCR-mediated signaling  |
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negatively regulated Toll-like receptor-mediated production of proinflammatory cytokines by inhibiting activation of the transcription factor NF-kappaB and mitogen-activated protein kinase |
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contributes to immune homeostasis by balancing the production of proinflammatory cytokines and type I interferons in the innate immune response |
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involved in the inhibition of CD2 signaling (represents a novel mechanism for direct T cell suppression by IL10) |
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playing an important role in airway mucin production through regulating oxidative stress |
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regulates cell growth, inflammation, and injury largely through negative signaling, as by inhibition of STATs, NF-KB, ERK, and the PI3 kinase-Akt pathway |
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regulates cell proliferation, whether it is by controlling mitogenic pathways activated by receptors with tyrosine kinase activity, or by regulating components of the cell-cycle machinery |
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intrinsic global regulator of dendritic cell function, controlling many facets of T cell-mediated immune responses |
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novel role for PTPN6 in the regulation of AKT1 activity through the modulation of the ghrelin/GHSR1a system signaling |
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regulates muscle insulin action in a cell-autonomous manner, further suggesting that the PTPase negatively modulates insulin action through down-regulation of both insulin signaling to AKT1 and SLC2A4 translocation, as well as SLC2A4 expression |
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negative regulator of proinflammatory signaling and autoimmune disease |
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key regulator of dendritic cell functions that protects against autoimmunity |
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role in the regulation of signaling or membrane fusion events involved in phagolysosome biogenesis |
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possible involvement of the PTPN6 phosphatase in regulating other NK functions in mature NK cells |
