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FLASH GENE
Symbol HSD11B2 contributors: mct/npt - updated : 17-03-2009
HGNC name hydroxysteroid (11-beta) dehydrogenase 2
HGNC id 5209
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a nucleotide binding domain
  • a catalytic domain
  • cluster of amino acids (335 to 339) in the C-terminus essential for protein stability (Atanasov 2007)
    • HOMOLOGY
    interspecies homolog to murine Hsd11b2
    Homologene
    FAMILY
  • short-chain dehydrogenase/reductase (SDR) family
    • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • hydroxysteroid dehydrogenase 11-beta 2, NAD dependent
  • interconversion of cortisol and cortisone
  • involved in the protection of mineralocorticoid receptor
  • functioning as a dehydrogenaseand enhancing glucocorticoids(GCs) deactivation (activity correlated with lower vascular resistance) (Gong 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate , hormone
    signaling
    glucocorticoid biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HSD11B2D
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly expressed in adrenal cortical carcinoma and adenoma
    Susceptibility to sodium handling and to response to thiazide diuretics
    Variant & Polymorphism other polymorphisms modifying sodium handling and response to thiazide diuretics
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS