Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HSD11B2 contributors: mct/npt - updated : 17-03-2009
HGNC name hydroxysteroid (11-beta) dehydrogenase 2
HGNC id 5209
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarykidneytubulecollecting duct  
cells
SystemCellPubmedSpeciesStageRna symbol
Urinaryepithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text adrenal gland, kidney, placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a nucleotide binding domain
  • a catalytic domain
  • cluster of amino acids (335 to 339) in the C-terminus essential for protein stability (Atanasov 2007)
    • HOMOLOGY
    interspecies homolog to murine Hsd11b2
    Homologene
    FAMILY
  • short-chain dehydrogenase/reductase (SDR) family
    • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • hydroxysteroid dehydrogenase 11-beta 2, NAD dependent
  • interconversion of cortisol and cortisone
  • involved in the protection of mineralocorticoid receptor
  • functioning as a dehydrogenaseand enhancing glucocorticoids(GCs) deactivation (activity correlated with lower vascular resistance) (Gong 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate , hormone
    signaling
    glucocorticoid biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HSD11B2D
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly expressed in adrenal cortical carcinoma and adenoma
    Susceptibility to sodium handling and to response to thiazide diuretics
    Variant & Polymorphism other polymorphisms modifying sodium handling and response to thiazide diuretics
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS