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FLASH GENE
Symbol TMPO contributors: mct - updated : 28-09-2016
HGNC name thymopoietin
HGNC id 11875
Corresponding disease
CMD1T cardiomyopathy dilated 1T
Location 12q23.1      Physical location : 98.909.350 - 98.944.157
Synonym name
  • Lamin A/C binding protein 2
  • lamina associated polypeptide 2
  • Synonym symbol(s) TP, LAP2, CMD1T, LEMD4, PRO0868, LAP2alpha
    DNA
    TYPE functioning gene
    STRUCTURE 34.81 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    FLJ31514 12q23.1 hypothetical protein FLJ31514 FLJ44112 12q23.1 FLJ44112 protein LOC387876 12 LOC387876 LOC390352 12 similar to eukaryotic translation elongation factor 1 alpha 1; CTCL tumor antigen; translation elongation factor 1 alpha 1-like 14; prostate tumor-inducing protein 1; EF1a-like protein; glucocorticoid receptor AF-1 specific elongati NEDD1 12q22 neural precursor cell expressed, developmentally down-regulated 1 LOC121456 12q23.1 similar to solute carrier family 9, member 7; nonselective sodium potassium/proton exchanger; sodium/hydrogen exchanger 7 TMPO 12q22-q23.1 thymopoietin LOC341457 12q23.1 similar to peptidyl-Pro cis trans isomerase SLC25A3 12q22-q23.1 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 LOC387877 FLJ31051 APAF1 12q23 apoptotic protease activating factor EB-1 12q23.1-q23.2 E2a-Pbx1-associated protein MGC39520 12q23.2 hypothetical protein MGC39520 LOC387878 12 similar to ribosomal protein S4, X-linked KIAA0701 12q23.1-q23.3 similar to ribosomal protein S4, X-linked DKFZp434M0331 12q23.3 hypothetical protein DKFZp434M0331 ACTR6 12q23.3 actin-related protein 6 FLJ33505 12q23.3 hypothetical protein FLJ33505 FLJ10074 12q23.3 hypothetical protein FLJ10074 SLC17A8 12q23.3 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 NR1H4 12q21.3 nuclear receptor subfamily 1, group H, member 4
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 splicing 3690 75 694 primary skin fibroblasts in a growth-dependent manner 1994 7517549
  • LAP2 alpha
  • nuclear isoform
  • splicing of the exon4
  • contains sequences encoding a putative basic nuclear localization
  • motif
  • a binding partner of lamins A/C
  • multiple and distinct functions of LAP2 alpha in muscle stem cell maintenance, early phases of myogenic differentiation, and muscle remodeling (PMID: 20039368)
  • 9 splicing 4186 51 454 over-expressed in gastric cancer tissues 1994 7517549
  • LAP2 beta
  • in the nuclear membrane
  • splicing of the exon 8
  • a hydrophobic putative membrane-spanning domain that is thought to target these 2 gene products to the nuclear membrane
  • regulates motility of cancer cells
  • 6 splicing 3853 39 345 - 1994 7517549
  • LAP2 gamma
  • in the nuclear membrane
  • splicing of the exon 8
  • a hydrophobic putative membrane-spanning domain that is thought to target these 2 gene products to the nuclear membrane
  • 8 - 4066 - 414 - 1994 7517549
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     thymus   highly
    Reproductivemale systemtestis  highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal LEM (LAP2, emerin, MAN1) globular domain of 40 AAs, LEM-like domain, which binds DNA
  • HOMOLOGY
    Homologene
    FAMILY LAP2 (lamina-associated protein 2) family
    CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome
    intracellular,nuclear envelope,int
    text
  • dynamically associating with chromatin during the cell cycle
  • nuclear periphery proteins LMNA, TMPO and BANF1 relocate to the spindle and the cell cortex in mitosis
  • basic FUNCTION
  • playing an important role, together with LMNA, in the nuclear anchorage of RB1
  • may be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly
  • playing a role with OIP5 during cell cycle exit, in which OIP5 acts upstream of TMPO
  • serves likely as a transcriptional co-regulator, which controls muscle specific gene expression during muscle regeneration, muscle remodeling and stress response
  • nuclear protein that connects the nuclear lamina with chromatin
  • and nucleoplasmic lamins are regulators of adult stem cell function and tissue homeostas
  • LMNA, TMPO and BANF1 are assembled into a protein complex during mitosis in order to regulate assembly and positioning of the mitotic spindle
  • in addition to its cell cycle-inhibiting function with LMNA, TMPO can also regulate extracellular matrix components independently of LMNA, which may help explain the proliferation-promoting function of TMPO in cells expressing progerin (pMID: 26443848)
  • novel role of nucleoplasmic lamin A/C and TMPO in regulating euchromatin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • TMPO-LMNA complex negatively affects cell proliferation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • hypophosphorylated RB is anchored in the nucleus by the interaction of pocket C with LAP2alpha-LMNA complexes
  • BANF1 and RB1 and with chromosomes
  • TMPO over-expression increased, while additional WNT4 secretion suppressed PPARG expression
  • N-terminal domain of HMGN5 interacts with the C-terminal domain of TMPO and these proteins reciprocally alter their interaction with chromatin
  • localizes throughout the nucleoplasm and interacts with the fraction of LMNA that is not associated with the peripheral nuclear lamina
  • LMNA localizes throughout the nucleus, where it associates with the chromatin-binding protein TMPO
  • cell & other
    REGULATION
    activated by during G1 phase in proliferating cells and upon cell cycle exit in quiescence, senescence and differentiation
    ASSOCIATED DISORDERS
    corresponding disease(s) CMD1T
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    of the LAP2 alpha isoform, in the LMNA binding region, in familial dilated cardiomyopathy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • LAP2beta may have utility for diagnostics and therapeutics in digestive tract cancers
  • Therapy target
    ANIMAL & CELL MODELS
  • in cardiac tissue, deletion of Tmpo caused systolic dysfunction in young mice with an increased susceptibility for fibrosis in old animals