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FLASH GENE

Symbol

TBX2

contributors: mct/pgu - updated : 29-08-2016

HGNC name	T-box 2
HGNC id	11597

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Tbx2 in the embryonic mouse heart at early stages of development throughout the myocardium of the heart tube both represses proliferation and impairs secondary heart field (SHF) progenitor cell deployment into the outflow tract (OFT), implicating the upregulation of Ndrg2 and downregulation of Ndrg4 expression
	lungs of Tbx2-deficient mice are markedly hypoplastic and exhibit reduced branching morphogenesis