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FLASH GENE

Symbol

TBX2

contributors: mct/pgu - updated : 29-08-2016

HGNC name	T-box 2
HGNC id	11597

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DEL17Q23

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     in primary breast and ovarian cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive uterus PSCA and TBX2 might be candidate targets for cancer therapy in endometrial adenocarcinoma

ANIMAL & CELL MODELS

	Tbx2 in the embryonic mouse heart at early stages of development throughout the myocardium of the heart tube both represses proliferation and impairs secondary heart field (SHF) progenitor cell deployment into the outflow tract (OFT), implicating the upregulation of Ndrg2 and downregulation of Ndrg4 expression
	lungs of Tbx2-deficient mice are markedly hypoplastic and exhibit reduced branching morphogenesis