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FLASH GENE
Symbol CSRP3 contributors: SGE/npt - updated : 21/10/2008
HGNC name cysteine and glycine-rich protein 3 (cardiac LIM protein)
HGNC id 2472
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N-terminal cysteine-rich LIM/double finger motifs (LIM domains)
  • a glycine-rich repeat (for the ACTN binding)
  • N-terminal half mediated activation of NPPA
    • HOMOLOGY
    interspecies homolog to murine Csrp3
    Homologene
    FAMILY
  • CSRF family
    • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text
  • sarcolemma
  • colocalizes with GLRX3 in the Z-disc
    • basic FUNCTION
  • essential nuclear regulator of myogenic differentiation
  • likely involved in the determination of cell lineage and regulation of cell differentiation
  • having crucial functions in the downstream signal transduction in response to mechanical stress and could involve improper response to myocardial stress sensing
  • actin-binding protein that increases actin cytoskeleton stability by promoting bundling of actin filaments
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • cytosolic component of cardiomyocytes and not tightly anchored to sarcomeric structures
  • forming a complex with CFL2 that is directly invovled in sarcomere dysfunction and disase, due to its role in regulating CFL2-dependent F actin depolymerization (Papalouka 2009)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to TCAP (Z disc MLP/TCAP complex, key component of the cardiomyocytes stretch sensor machinery)
  • ACTN2
  • modulating the transcriptional activity of HEN1
  • interacting with TCAP (Knoll (2002)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMD1M
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS