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FLASH GENE

Symbol

CSRP3

contributors: SGE/npt - updated : 21/10/2008

HGNC name	cysteine and glycine-rich protein 3 (cardiac LIM protein)
HGNC id	2472

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	20.02 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003476 6 - 1341 NP_003467 21 194 - Zheng (2008) NM_001127656 6 - 1286 NP_001121128 21 194 - Zheng (2008)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Reproductive male system prostate     lowly Respiratory lung       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum cardiac   highly Muscular striatum skeletal   highly

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

pancreas

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two N-terminal cysteine-rich LIM/double finger motifs (LIM domains)
	a glycine-rich repeat (for the ACTN binding)
	N-terminal half mediated activation of NPPA

HOMOLOGY

interspecies

homolog to murine Csrp3

Homologene

FAMILY

CSRF family

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton
	intracellular,nucleus
text	sarcolemma
	colocalizes with GLRX3 in the Z-disc

basic FUNCTION	essential nuclear regulator of myogenic differentiation
	likely involved in the determination of cell lineage and regulation of cell differentiation
	having crucial functions in the downstream signal transduction in response to mechanical stress and could involve improper response to myocardial stress sensing
	actin-binding protein that increases actin cytoskeleton stability by promoting bundling of actin filaments

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	cytosolic component of cardiomyocytes and not tightly anchored to sarcomeric structures
	forming a complex with CFL2 that is directly invovled in sarcomere dysfunction and disase, due to its role in regulating CFL2-dependent F actin depolymerization (Papalouka 2009)

INTERACTION

DNA

RNA

small molecule

protein	binding to TCAP (Z disc MLP/TCAP complex, key component of the cardiomyocytes stretch sensor machinery)
	ACTN2
	modulating the transcriptional activity of HEN1
	interacting with TCAP (Knoll (2002)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CMD1M

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS