Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NXT1 contributors: mct - updated : 29-09-2020
HGNC name NTF2-like export factor 1
HGNC id 15913
Location 20p11.21      Physical location : 23.331.372 - 23.335.408
Synonym name
  • MTR2 yeasr homolog
  • NUTF-like export factor 1
  • protein p15
  • Synonym symbol(s) P15, MTR2
    DNA
    TYPE functioning gene
    STRUCTURE 3.98 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1062 - 140 - 2016 27483302
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Lymphoid/Immunelymph node    
    Reproductivefemale systemuterus   
     female systemovary   
     male systemtestis   
    Respiratorylung    
    Skin/Tegumentskin    
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one NTF2 domain
  • a long internal loop, which contains residues that affect the export of the large ribosomal subunit
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • playing a role in the nuclear export of U1 snRNA, tRNA,
  • and mRNA
  • NXF1/NXT1 heterodimer enhances nucleoporin binding and induces the formation of a NXF1/NXT1/nucleoporin ternary complex, a key intermediate in the process of nuclear mRNA export
  • may act as a molecular switch that regulates the ability of NXF1 to mediate nuclear mRNA export by controlling the interaction of NXF1 with components of the nuclear pore
  • nuclear export of mRNAs is mediated by the NXF1/NXT1 pathway
  • role for this gene in tissue specific transcription
  • NXF2 and its co-factor, NXT1, form a complex with PANX and are required for co-transcriptional silencing of transposons in somatic and germline cells of the ovary
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimerizing with NXF1
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cofactor for NXF1-mediated mRNA export
  • NXT1 is a novel member of the NTF2-like family and interacts with NXF1, forming a complex with a similar structural architecture to that of NXF1/NXT1
  • NXT1/NXF1 recognizes bulk mRNAs through combinatorial use of the distinct RNA binding domains
  • NXT1 is a novel binding partner of nucleoprotein (NP) that stimulates NP-mediated nuclear export via the XPO1-dependent pathway
  • NXT1 binds to the C-terminal region of NP
  • sNXF1 can replace NXT1 to enhance the expression of CTE-containing mRNA and promote its association with polyribosomes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinfectious 
    NXT1/NP interaction is a potential target for antiviral drug development
    ANIMAL & CELL MODELS