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FLASH GENE
Symbol NUDT9 contributors: - updated : 03-11-2006
HGNC name nudix (nucleoside diphosphate linked moiety X)-type motif 9
HGNC id 8056
Location 4q22.1      Physical location : 88.343.734 - 88.379.497
Synonym name ADP-ribose pyrosphosphatase NUDT9
Synonym symbol(s) MGC3037,NUDT10,
DNA
TYPE functioning gene
STRUCTURE 35.00 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1716 39.13 350 - Perraud
- - 1703 - 350 - Perraud
- splicing 1379 - 300 - Perraud
a potentially aberrant splice from a cryptic donor site within the first exon
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Lymphoid/Immunespleen    
Reproductivemale systemtestis   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • a N-terminal enhancing the affinity of C-terminal domain for ADPR domain
  • a C-terminal Nudix domain.
  • a C-terminal catalytic domain reaining full specific ADPR pyrophosphatase activity
  • mono polymer heteromer
    HOMOLOGY
    Homologene
    FAMILY NUDIX hydrolase family
    CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text
  • MUDT9a targeted to mitochondria
  • NUDT9b without clear subcellular localization
  • basic FUNCTION
  • hydrolyzing ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. having calcium activated cation channel activity
  • hydrolase activities
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • requiring divalent cations
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS