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FLASH GENE
Symbol NPM3 contributors: SGE/npt/pgu - updated : 08-03-2010
HGNC name nucleophosmin/nucleoplasmin 3
HGNC id 7931
Location 10q24.32      Physical location : 103.541.082 - 103.543.170
Synonym name
  • nucleoplasmin-3
  • nucleophosmin/nucleoplasmin family, member 3
  • Synonym symbol(s) PORMIN, TMEM123
    DNA
    TYPE functioning gene
    STRUCTURE 2.09 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 904 - 178 - 1997 9177783
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Npm3 (86.9pc)
    homolog to rattus Npm3 (85.0pc)
    Homologene
    FAMILY
  • nucleophosmin/nucleoplasmin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • lacking intrinsic histone chaperone activity
  • inhibits histone assembly activity of NPM1 and dramatically enhances transcription
  • the NPM proteins (NPM1, NPM2, NPM3) cooperatively regulate chromatin disassembly and assembly in the early embryo and in somatic cells
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TNP2
  • NPM3 suppressed the RNA-binding activity of NPM1, which enhanced the nucleoplasm-nucleolus shuttling of NPM1 in somatic cell nuclei
  • beyond their important role in the remodeling of paternal chromatin in the early stages of embryogenesis, NPM2 and NPM3 and NASP members can interact with a plethora of proteins in addition to histones in somatic cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS