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FLASH GENE
Symbol GIPR contributors: mct - updated : 29-05-2012
HGNC name gastric inhibitory polypeptide receptor
HGNC id 4271
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal part crucial for biological activity
  • AAs involved in functional interaction with N-terminal moiety of GIP
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Gipr
    ortholog to murine Gipr
    Homologene
    FAMILY
  • family B of the G-protein coupled receptors
  • G-protein coupled receptor 2 family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral to plasma membrane
    basic FUNCTION
  • acting as a gastric inhibitory polypeptide receptor
  • may play a critical role in adipocyte development
  • might represent a gene expressed early in terminal differentiation and thus plays a role in fat droplet formation
  • putative modulatory functions of GIP/GIPR signaling in adult neurons
  • critical role of GIP/GIPR signal transduction in promoting spontaneous recovery after nerve crush
  • implication of GIPR in insulin secretion
  • role in the incretin effect and in early pathophysiologic pathways that could lead to impaired glucose tolerance and T2D
  • GLP1R, GIPR, and GCGR internalize with differential properties
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    activity of this receptor is mediated by G proteins which
    activate adenylyl cyclase
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cross-talk between the two incretin receptors GLP1R and GIPR is shown to alter receptor trafficking with functional consequences for GLP1R signaling
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to obesity
    Variant & Polymorphism other variants associated to obesity
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    obesity  
    might represent a suitable target for the treatment of obesity
    ANIMAL & CELL MODELS