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FLASH GENE

Symbol

GIPR

contributors: mct - updated : 29-05-2012

HGNC name	gastric inhibitory polypeptide receptor
HGNC id	4271

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Digestive intestine large intestine colon   moderately Endocrine pancreas islet of Langerhans     predominantly Homo sapiens Nervous brain       moderately Respiratory lung       highly Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cells

System Cell Pubmed Species Stage Rna symbol Endocrine islet cell (alpha,beta...) Homo sapiens Nervous oligodendrocyte Nervous Schawnn cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal part crucial for biological activity
	AAs involved in functional interaction with N-terminal moiety of GIP

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to rattus Gipr
	ortholog to murine Gipr

Homologene

FAMILY	family B of the G-protein coupled receptors
	G-protein coupled receptor 2 family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
text	integral to plasma membrane

basic FUNCTION	acting as a gastric inhibitory polypeptide receptor
	may play a critical role in adipocyte development
	might represent a gene expressed early in terminal differentiation and thus plays a role in fat droplet formation
	putative modulatory functions of GIP/GIPR signaling in adult neurons
	critical role of GIP/GIPR signal transduction in promoting spontaneous recovery after nerve crush
	implication of GIPR in insulin secretion
	role in the incretin effect and in early pathophysiologic pathways that could lead to impaired glucose tolerance and T2D
	GLP1R, GIPR, and GCGR internalize with differential properties

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

	activity of this receptor is mediated by G proteins which
	activate adenylyl cyclase

a component

INTERACTION

DNA

RNA

small molecule

protein

cross-talk between the two incretin receptors GLP1R and GIPR is shown to alter receptor trafficking with functional consequences for GLP1R signaling

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to obesity

Variant & Polymorphism other	variants associated to obesity

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed obesity     might represent a suitable target for the treatment of obesity

ANIMAL & CELL MODELS