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FLASH GENE
Symbol NKX2-8 contributors: mct/npt - updated : 03-07-2009
HGNC name NK2 homeobox 8
HGNC id 16364
DNA
TYPE functioning gene
SPECIAL FEATURE head to head, opposite orientation
text head to head with PAX9
STRUCTURE 2.57 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1857 25.7 239 - Kajiyama (2002)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one homeobox domain
    • HOMOLOGY
    intraspecies paralog to TITF1
    Homologene
    FAMILY
  • NK-2 homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • homeodomain transcription factor, having a role in progenitor cells in the large airways and leads to dysplasia (Tian 2006)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding promoter-coupling element and regulating expression of alpha-fetoprrotein (AFP) gene
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    coactivation of NKX2-1 and NKX2–8 pathways in non-small-cell lung cancer resistant to standard cisplatin therapy and with poor prognosis (Hsu 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS