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FLASH GENE
Symbol NKX2-8 contributors: mct/npt - updated : 03-07-2009
HGNC name NK2 homeobox 8
HGNC id 16364
Location 14q13.3      Physical location : 37.049.216 - 37.051.786
Synonym name
  • NK-2 (Drosophila) homolog 8
  • NK2 transcription factor related, locus 8 (Drosophila)
  • homeobox protein NK-2 homolog H
    • Synonym symbol(s) NKX2H, Nkx2-9, NKX2G
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head, opposite orientation
    text head to head with PAX9
    STRUCTURE 2.57 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1857 25.7 239 - Kajiyama (2002)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one homeobox domain
    • HOMOLOGY
    intraspecies paralog to TITF1
    Homologene
    FAMILY
  • NK-2 homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • homeodomain transcription factor, having a role in progenitor cells in the large airways and leads to dysplasia (Tian 2006)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding promoter-coupling element and regulating expression of alpha-fetoprrotein (AFP) gene
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    coactivation of NKX2-1 and NKX2–8 pathways in non-small-cell lung cancer resistant to standard cisplatin therapy and with poor prognosis (Hsu 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS