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FLASH GENE
Symbol MYRIP contributors: mct - updated : 15-02-2019
HGNC name myosin VIIA and Rab interacting protein
HGNC id 19156
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal SlP HO domain (SHD)
  • a C terminal,myosin binding domain
  • a most C terminal actin binding conserved region
    • HOMOLOGY
    interspecies ortholog to murine Myrip
    Homologene
    FAMILY AKAP family
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytoskeleton
    intracellular,nuclear envelope
    text melanosomes
    basic FUNCTION
  • RAB27 effector
  • RAB27A, MYRIP and MYO7A bridges retinal melanosomes to the actin cytoskeleton and thereby mediates the local trafficking of these organelles
  • functions as a scaffolding protein that links PRKA to components of the exocytosis machinery
  • versatile RAB27A-associated myosin-activating protein that mediates cellular activation of MYO5A and MYO7A via non-overlapping domains
  • effector protein of the small GTPase RAB27A and is specifically localized on retinal melanosomes and secretory granules
  • transiently traps insulin granules into the cortical actin network close to the microtubule plus-ends and supplies them for release during the stimulation
  • MYRIP couples the retention of secretory granules (SGs) in the cell cortex, their transport to the PM, and their attachment to the plasma membrane (PM), and thus promotes secretion
  • is implicated in hormone secretion, and MYRIP is important for beta-cell function
  • reported to play a role in anchoring secretory granules within the actin cortex, due to its direct binding activities to RAB27A on the granule membrane and to F-actin and its motor protein, MYO5A
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • complex with RAB27A and MYO7A bridging retinal melanosomes to actin skeleton
  • MYO5A forms a tripartite complex with RAB27A and its effector MYRIP
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to MYO5A, MYO7A, RABZ7A/B (GTP bound form), actin
  • interacts with MYO5A lacking melanocyte-specific exon F
  • MYRIP functionally links insulin vesicle transport and GCG signaling
  • role of MYRIP in regulating Weibel-Palade body (WPB) trafficking and exocytosis is mediated largely through its interaction with actin rather than with MYO5A
  • MYRIP accumulates granules in the cortical F-actin network not by direct interaction with MYO5A, but by indirect interaction with a specific form of MYO7A through its previously unknown binding partner, RIMBP2 (28673385)
    • cell & other melanosomes
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS