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FLASH GENE

Symbol

MYRIP

contributors: mct - updated : 15-02-2019

HGNC name	myosin VIIA and Rab interacting protein
HGNC id	19156

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Urinary kidney         Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining retinal pigment epithelium (RPE)

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument melanocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal SlP HO domain (SHD)
	a C terminal,myosin binding domain
	a most C terminal actin binding conserved region

HOMOLOGY

interspecies

ortholog to murine Myrip

Homologene

FAMILY

AKAP family

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,granule
	intracellular,cytoplasm,cytoskeleton
	intracellular,nuclear envelope
text	melanosomes

basic FUNCTION	RAB27 effector
	RAB27A, MYRIP and MYO7A bridges retinal melanosomes to the actin cytoskeleton and thereby mediates the local trafficking of these organelles
	functions as a scaffolding protein that links PRKA to components of the exocytosis machinery
	versatile RAB27A-associated myosin-activating protein that mediates cellular activation of MYO5A and MYO7A via non-overlapping domains
	effector protein of the small GTPase RAB27A and is specifically localized on retinal melanosomes and secretory granules
	transiently traps insulin granules into the cortical actin network close to the microtubule plus-ends and supplies them for release during the stimulation
	MYRIP couples the retention of secretory granules (SGs) in the cell cortex, their transport to the PM, and their attachment to the plasma membrane (PM), and thus promotes secretion
	is implicated in hormone secretion, and MYRIP is important for beta-cell function
	reported to play a role in anchoring secretory granules within the actin cortex, due to its direct binding activities to RAB27A on the granule membrane and to F-actin and its motor protein, MYO5A

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component	complex with RAB27A and MYO7A bridging retinal melanosomes to actin skeleton
	MYO5A forms a tripartite complex with RAB27A and its effector MYRIP

INTERACTION

DNA

RNA

small molecule

protein	binding to MYO5A, MYO7A, RABZ7A/B (GTP bound form), actin
	interacts with MYO5A lacking melanocyte-specific exon F
	MYRIP functionally links insulin vesicle transport and GCG signaling
	role of MYRIP in regulating Weibel-Palade body (WPB) trafficking and exocytosis is mediated largely through its interaction with actin rather than with MYO5A
	MYRIP accumulates granules in the cortical F-actin network not by direct interaction with MYO5A, but by indirect interaction with a specific form of MYO7A through its previously unknown binding partner, RIMBP2 (28673385)

cell & other

melanosomes

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS