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FLASH GENE
Symbol MUC17 contributors: mct - updated : 20-08-2010
HGNC name mucin 17, cell surface associated
HGNC id 16800
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extended, repetitive extracellular glycosylation domain,
  • extracellular regions with two EGF-like Cys-rich domains (CRD1 and CRD2) connected by an intervening linker segment with SEA module (L), that may function to stimulate intestinal cell restitution
  • a SEA module domain
  • a transmembrane domain
  • a cytoplasmic domain with potential serine and tyrosine phosphorylation sites
    • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to murine Muc3
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • extracellular matrix constituent, lubricant activity
  • both native MUC17 and the exogenous recombinant cysteine-rich domain of MUC17 play a role in diverse cellular mechanisms related to cell restitution
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • exhibited a strong binding to PDZK1 (PDZK1 plays a specific role in stabilizing MUC17 in the apical membrane of small intestinal enterocytes)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in colonic mucosa of chronic ulcerative colitis and ischaemic colitis
    tumoral     --low  
    decreased in hyperplastic polyps, tubular and tubulovillous adenomas and colon cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmunedigestive
    potential role for MUC17-CRD1-L-CRD2 recombinant protein in the treatment of mucosal inflammatory diseases
    ANIMAL & CELL MODELS