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FLASH GENE
Symbol MT-ND4L contributors: np - updated : 13-03-2006
HGNC name mitochondrially encoded NADH dehydrogenase 4L
HGNC id 7460
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
mono polymer heteromer , complex
HOMOLOGY
interspecies ortholog to murine Mt-Nd4l
homolog to C.elegans Y58A7A.2
Homologene
FAMILY complex I subunit 4L family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
basic FUNCTION
  • catalysing reduction of ubiquinone on ubiquinol by NADH in the respiratory chain
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic
    signaling
    a component
  • one of the forty one subunits of complex 1, probably located in the hydrophobic fragment
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LHON
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS