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FLASH GENE
Symbol MT-ND2 contributors: np/ - updated : 13-03-2006
HGNC name mitochondrially encoded NADH dehydrogenase 2
HGNC id 7456
DNA
TYPE functioning gene
STRUCTURE 1.00 kb     1 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
mono polymer heteromer , complex
HOMOLOGY
interspecies ortholog to murine Mt-Nd2
homolog to C.elegans T06G6.1
Homologene
FAMILY complex I subunit 2 family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
basic FUNCTION
  • catalysing reduction of ubiquinone on ubiquinol by NADH in the respiratory chain
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • one of the forty one subunits of complex 1, probably in the hydrophobic protein fragment
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LHON
    Susceptibility to myocardial infarction
    Variant & Polymorphism other haplotype N9B confering resistance against myocardial infarction
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS