Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MFRP contributors: mct - updated : 14-01-2011
HGNC name membrane frizzled-related protein
HGNC id 18121
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • CRD : frizzled type cystein rich domain, essential for WNT binding and signaling
  • two MFRP domains
  • two CUB domains
  • one C1q domain
  • one collagen-like domain
    • HOMOLOGY
    interspecies ortholog to murine Mfrp
    Homologene
    FAMILY
  • frizzled-related protein family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II transmembrane protein
    basic FUNCTION
  • acting as a possible regulator of the WNT signaling pathway
  • playing a role in regulating axial length of the eye
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to WNT maybe
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NNO2 , MPRF
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS