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FLASH GENE

Symbol

MMP12

contributors: mct - updated : 30-11-2015

HGNC name	matrix metalloproteinase 12 (macrophage elastase)
HGNC id	7158

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in ulcerative colitis and Crohn's disease and in colorectal carcinoma with better prognosis constitutional     --over   with ADAMDEC1, in bronchoalveolar lavage samples from patients with sarcoidosis, correlating with disease severity tumoral     --over   correlated with poor prognosis of hepatocellular carcinoma constitutional     --over   in atherosclerotic lesions

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	MMP12 mRNA may be a valuable prognostic marker for both overall survival and tumour recurrence of hepatocellular carcinoma patients after liver resection
Therapy target
	System Type Disorder Pubmed allergy asthm   In allergen-sensitized sheep pharmacologic inhibition of MMP12 downregulates both early and late airway responses in response to allergic stimuli

ANIMAL & CELL MODELS