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FLASH GENE
Symbol MAT2B contributors: mct - updated : 04-02-2014
HGNC name methionine adenosyltransferase II, beta
HGNC id 6905
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • two prominent hydropholic segments
    • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • dTDP-4-dehydrorhamnose reductase family
  • MAT2B subfamily
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • inhibiting the methionine adenosyl-transferase II
  • regulatory subunit of the methionine adenosyl-transferase II
  • MAT2B and GIT1 form a scaffold, which recruits and activates MEK and ERK to promote growth and tumorigenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to alpha1 membrane subunit of MAT I/III
    • cell & other
    REGULATION
    induced by SP3,SP1
    Other phosphorylation of MAT2A, MAT2B proteins during hepatic stellate cells (HSCs) activation stabilizes them thereby positively regulating trans-differentiation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS