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FLASH GENE

Symbol

MAT2B

contributors: mct - updated : 04-02-2014

HGNC name	methionine adenosyltransferase II, beta
HGNC id	6905

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q34-q35.1      Physical location : 162.930.230 - 162.946.325
Synonym name	dTDP-4-keto-6-deoxy-D-glucose 4-reductase
	beta regulatory subunit of methionine
	adenosyltransferase
	short chain dehydrogenase/reductase family 23E, member 1
	putative protein product of Nbla02999
Synonym symbol(s)	TGR, MATII, MATIIbeta, SDR23E1, MGC12237, Nbla02999
EC.number	2.5.1.6

DNA

TYPE	functioning gene
STRUCTURE	16.09 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter (TATA box)
	cytosine-phosphate-guanine/HTF
	Binding site   enhancer   transcription factor
text structure	SP1 sites
	NF1 sites

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 2090 37.42 334 - LeGros (2000) variant 2 - - 2119 36.3 323 - LeGros (2000)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Endocrine pancreas         Nervous brain       highly Reproductive male system testis         male system prostate     highly Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid         Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte

cell lineage
cell lines	leukemic cell lines
fluid/secretion

at STAGE

physiological period

fetal

Text

liver

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains

two prominent hydropholic segments

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY	dTDP-4-dehydrorhamnose reductase family
	MAT2B subfamily

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION

intracellular

basic FUNCTION	inhibiting the methionine adenosyl-transferase II
	regulatory subunit of the methionine adenosyl-transferase II
	MAT2B and GIT1 form a scaffold, which recruits and activates MEK and ERK to promote growth and tumorigenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

aminoacid

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binding to alpha1 membrane subunit of MAT I/III

cell & other

REGULATION

induced by

SP3,SP1

Other

phosphorylation of MAT2A, MAT2B proteins during hepatic stellate cells (HSCs) activation stabilizes them thereby positively regulating trans-differentiation

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS