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FLASH GENE
Symbol MAPK13 contributors: mct - updated : 04-02-2009
HGNC name mitogen-activated protein kinase 13
HGNC id 6875
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a protein kinase domain
  • a nucleotide phosphate binding region
  • an ATP binding site
    • HOMOLOGY
    interspecies ortholog to murine Mapk13
    homolog to Drosophila p38b
    homolog to C.elegans pmk-1
    intraspecies homolog to p38 alpha
    homolog to p38 beta
    homolog to p38 gamma
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • MAP kinase subfamily
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • having a protein serine/threonine kinase activity
  • phosphorylating transcription factor and downstreams targets
    • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    protein, translation regulation
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    text microbial antihumoral response
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • ATP
  • Mg2+
    • protein
    cell & other
    REGULATION
    activated by LBP and CD14
    induced by environmental stress
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS