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FLASH GENE
Symbol PTGR1 contributors: npt/ - updated : 23-01-2008
HGNC name prostaglandin reductase 1
HGNC id 18429
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a NADP binding site
  • a C terminal proline rich motif
    • mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • NADP-dependent oxidoreductase L4BD family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalysing the conversion of leukotriene B4 into its biologically less reactive metabolite 12-oxo-leukotriene B4, a key step for its inactivation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    leukotriene
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
  • NADP
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS