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FLASH GENE
Symbol LHX9 contributors: mct - updated : 03-10-2018
HGNC name LIM homeobox 9
HGNC id 14222
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two LIM zinc-binding domains
  • an homeobox domain
    • conjugated MetalloP
    HOMOLOGY
    interspecies ortholog to murine Lhx9
    Homologene
    FAMILY LIM-homeodomain gene family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in gonadal development
  • LHX2 and LHX9 determine neuronal differentiation and compartition in the caudal forebrain by regulating Wnt signaling
  • controls pineal gland development and prevents postnatal hydrocephalus
  • is a member of the LIM-homeodomain gene family necessary for the correct development of many organs including gonads, limbs, heart and the nervous system
  • LHX9 is a new molecular marker that defines a subset of amacrine cells
  • LHX9 is indispensable for testis development and testosterone production
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development , reproduction/sex
    PATHWAY
    metabolism
    signaling
  • requirement for the LHX9-integrin-paxillin pathway in proepicardial organ positioning and epicardial formation
    • a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • LHX9 gene represents the first direct target of the GATA4/ZFPM2 repressor complex in cardiac development
  • LHX2 binds to a conserved motif in the ROBO3 gene, suggesting that LHX2/LHX9 regulate directly the expression of ROBO3
  • LMO3 is a putative direct transcriptional target of GBX2 (GBX2 regulates the LIM transcriptional codes comprising LHX2, LHX9 and LMO3, which subsequently control the differential expression of ROBO1 and ROBO2 in the thalamus
  • GBX2 negatively regulates the transcription of LHX9 in the thalamus
  • LHX9 expression overlaps with FGF10 expression in the developing limb bud mesenchyme
  • SMURF1, an E3 ubiquitin ligase, targets LHX9 for ubiquitin-mediated proteasome degradation, thereby negatively modulating its function
  • SMURF1 promotes LHX9 ubiquitylation and is involved in testosterone production in Leydig cells directly
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS