| Symbol
| MMP14
| contributors: mct - updated : 22-10-2016
|
| HGNC name
| matrix metalloproteinase 14 (membrane-inserted)
|
| HGNC id
| 7160
|
| corresponding disease(s)
|
WINCH2
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
| |
in oral squamous cell carcinoma (OSCC) with lymph node metastasis | | constitutional
|
|
| --over
|
| |
in keratoconus cornea | | tumoral
|
|
|
| gain of function
| |
in head and neck cancer (by CSF2)and in melanoma in progression | | tumoral
|
|
| --over
|
|
in glioma-associated microglia  | | constitutional
|
|
| --over
|
| |
reduced corneal opacity and expression of the major genes involved in corneal scarring, especially type III collagen and alpha-smooth muscle actin | | tumoral
|
|
| --over
|
| |
in human gastric cancer and its association with tumor progression | |
| Susceptibility
|
to chronic obstructive pulmonary |
| Variant & Polymorphism
other
| haplotype -165 T : +221 T : +6727 C : +7096 C, might be involved in the pathogenesis of chronic obstructive pulmonary disease |
| 
|
| Candidate gene
| tyrosine-phosphorylated MMP14 plays an important role in neuroblastoma progression and its expression is preferentially observed in tumor specimens from neuroblastoma patients showing poor clinical outcome |
Marker
Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| cancer | brain | | |
| targeted inhibition of MMP14 or SLC37A4 may lead to reduced infiltrative and invasive properties of brain tumor cells |
| | |
|
| Mt1-Mmp-/- mice had a lower number of empty lacunae and a higher osteocyte density |