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FLASH GENE
Symbol KREMEN2 contributors: mct/npt - updated : 04/10/2008
HGNC name kringle containing transmembrane protein 2
HGNC id 18797
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • a kringle domain
  • a WSC
  • a CUB domain and four glycosylation sites in the extracellular region
    • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • DKK receptor, cooperating with DKK1 to block WNT, beta catenin signaling pathway
  • inducing exocytosis, cell cell interaction
  • not universally required for DKK1 function
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , cell to cell transport , exocytosis transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of a ternary complex with DKK1 and the lipoprotein related protein - (LRP6)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to LRP6, KREMEN1
  • with KREMEN1, identified to be the high-affinity receptors for Dickkopf (Dkk), the inhibitor of Wnt/beta-catenin signalling
  • functional interaction of Kremen proteins with DKK1 as negative regulators of Wnt/beta-catenin signaling
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS