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FLASH GENE

Symbol

KREMEN2

contributors: mct/npt - updated : 04/10/2008

HGNC name	kringle containing transmembrane protein 2
HGNC id	18797

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	4.16 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed KREMEN2a - splicing codon stop 2276 46.6 424 - Mao containing an additional segment in the 3' coding region producing a frameshift KREMEN2b 8 splicing codon stop 1992 46.2 420 - Mao (2002) lacking an exon in the 3' coding region KREMEN2c - splicing codon stop 2356 43.9 399 - Mao containing an additional segment in the 3' coding region producing a frameshift KREMEN2d 9 splicing codon stop 2071 48.9 462 - Mao (2002)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       highly Reproductive female system uterus cervix   highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal peptide
	a kringle domain
	a WSC
	a CUB domain and four glycosylation sites in the extracellular region

conjugated

GlycoP

isoforms

Precursor

HOMOLOGY

Homologene

FAMILY

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
text	type I transmembrane protein

basic FUNCTION	DKK receptor, cooperating with DKK1 to block WNT, beta catenin signaling pathway
	inducing exocytosis, cell cell interaction
	not universally required for DKK1 function

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , cell to cell transport , exocytosis transport

PATHWAY

metabolism

signaling

signal transduction

a component

component of a ternary complex with DKK1 and the lipoprotein related protein - (LRP6)

INTERACTION

DNA

RNA

small molecule

protein	binding to LRP6, KREMEN1
	with KREMEN1, identified to be the high-affinity receptors for Dickkopf (Dkk), the inhibitor of Wnt/beta-catenin signalling
	functional interaction of Kremen proteins with DKK1 as negative regulators of Wnt/beta-catenin signaling

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS