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FLASH GENE
Symbol KLF16 contributors: - updated : 08-06-2005
HGNC name Kruppel-like factor 16
HGNC id 16857
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a proline and alanine rich domain
  • three zinc finger motifs of the C2H2 type forming a DNA binding domain
    • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to Drosophila EP2237
    ortholog to murine Klf16
    intraspecies homolog to BTEB1
    Homologene
    FAMILY Sp1-like family of GC box binding transcription factors
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as a modulator of dopamine receptor through binding to DR promoters
  • repressing CYP1A1 gene promoter via the BTE site
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    modulating dopaminergic transmission in brain
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein binding to SIN3A
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS