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FLASH GENE
Symbol KCNH8 contributors: mct - updated : 04-03-2014
HGNC name potassium voltage-gated channel, subfamily H (eag-related), member 8
HGNC id 18864
Location 3p24.3      Physical location : 19.190.016 - 19.577.135
Synonym name
  • ELK channel 3
  • voltage-gated potassium channel subunit Kv12.1
  • ether-a-go-go-like potassium channel 1
  • ether-a-go-go-like potassium channel 3
  • Synonym symbol(s) Kv12.1, ELK, ELK1, elk3
    DNA
    TYPE functioning gene
    STRUCTURE 387.19 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 5106 123.7 1107 - 2003 12890647
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal cytoplasmic domain, containing an EAG domain, which is composed of a Per-Arnt-Sim (PAS) dimerization domain and a PAS-cap domain,
  • PAC (PAS-associated C-terminal) domain
  • six transmembrane domains the fourth being the voltage-sensor site
  • a pore forming domain (H5) between the fifth and sixth transmembrane domains
  • two N-glycosylation site
  • C-terminal region containing a cyclic-nucleotide-binding homology domain (CNBHD) and C-linker that couples the CNBHD to the pore
  • mono polymer homomer , heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • potassium channel family
  • H (EAG) subfamily
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • pore forming (alpha) subunit of voltage-gated potassium channel
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • cyclic nucleotide (cAMP)
  • protein
  • CACNA2D2 and KCNH8, appeared to be regulated by CTNNB1, although the binding of CTNNB1 to the regulatory sequences of these genes could not be confirmed
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS