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FLASH GENE
Symbol KCNH7 contributors: mct/npt - updated : 05-03-2014
HGNC name potassium voltage-gated channel, subfamily H (eag-related), member 7
HGNC id 18863
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
nervousbraindiencephalon   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines prolactine adenoma
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal cytoplasmic domain
  • PAS (PER-ARNT-SIM) dimerization domain
  • PAC (PAS-associated C-terminal ) domain
  • six transmembrane domains the fourth being the voltage-sensor site
  • a pore forming domain (H5) between the fifth and sixth transmembrane domains
  • a N glycosylation site
  • C-terminal region containing a cyclic-nucleotide-binding homology domain (CNBHD) and C-linker that couples the CNBHD to the pore
  • conjugated GlycoP
    mono polymer homomer , heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • potassium channel family
  • H (EAG) subfamily
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • pore forming (alpha) subunit of voltage-gated potassium channel
  • selectively involved in proliferation of distinct uterine cancer cells (Suzuki 2004)
  • forms the ion channel responsible for the rapidly acting delayed rectifier potassium current, I(Kr), and its blockade is a significant contributor to prolongation of the QT interval (Yoshida 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    text prolactine secretion
    PATHWAY
    metabolism
    signaling
    a component
  • KCNH2, KCNH6
  • part of ERG channels control the excitability of medial vestibular nucleus neurones, their discharge regularity and probably their resonance properties (Pessia 2008)
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • cyclic nucleotide (cAMP)
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS