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FLASH GENE

Symbol

KCNH7

contributors: mct/npt - updated : 05-03-2014

HGNC name	potassium voltage-gated channel, subfamily H (eag-related), member 7
HGNC id	18863

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	467.32 kb     16 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_033272 16 splicing polyA site codon stop 4225 NP_150375 135 1196 - 1999 1041430 NM_173162 8 splicing polyA site codon stop 2488 NP_775185 - 732 - 1999 1041430

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         nervous brain diencephalon       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cell lineage
cell lines	prolactine adenoma
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal cytoplasmic domain
	PAS (PER-ARNT-SIM) dimerization domain
	PAC (PAS-associated C-terminal ) domain
	six transmembrane domains the fourth being the voltage-sensor site
	a pore forming domain (H5) between the fifth and sixth transmembrane domains
	a N glycosylation site
	C-terminal region containing a cyclic-nucleotide-binding homology domain (CNBHD) and C-linker that couples the CNBHD to the pore

conjugated

GlycoP

mono polymer

homomer , heteromer , tetramer

HOMOLOGY

Homologene

FAMILY	potassium channel family
	H (EAG) subfamily

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	pore forming (alpha) subunit of voltage-gated potassium channel
	selectively involved in proliferation of distinct uterine cancer cells (Suzuki 2004)
	forms the ion channel responsible for the rapidly acting delayed rectifier potassium current, I(Kr), and its blockade is a significant contributor to prolongation of the QT interval (Yoshida 2006)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

facilitated diffusion transport

text	prolactine secretion

PATHWAY

metabolism

signaling

a component	KCNH2, KCNH6
	part of ERG channels control the excitability of medial vestibular nucleus neurones, their discharge regularity and probably their resonance properties (Pessia 2008)

INTERACTION

DNA

RNA

small molecule	nucleotide,
	cyclic nucleotide (cAMP)

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS