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FLASH GENE
Symbol KCNH7 contributors: mct/npt - updated : 05-03-2014
HGNC name potassium voltage-gated channel, subfamily H (eag-related), member 7
HGNC id 18863
Location 2q24.2      Physical location : 163.227.916 - 163.695.240
Synonym name
  • eag related protein 3
  • voltage-gated potassium channel subunit Kv11.3
  • potassium channel subunit HERG-3
  • ether-a-go-go related gene potassium channel 3
    • voltage-gated potassium channel subunit Kv11.3
    Synonym symbol(s) HERG3, HERG-3, Kv11.3, MGC45986
    DNA
    TYPE functioning gene
    STRUCTURE 467.32 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 splicing polyA site codon stop 4225 135 1196 - 1999 1041430
    8 splicing polyA site codon stop 2488 - 732 - 1999 1041430
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    nervousbraindiencephalon   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines prolactine adenoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal cytoplasmic domain
  • PAS (PER-ARNT-SIM) dimerization domain
  • PAC (PAS-associated C-terminal ) domain
  • six transmembrane domains the fourth being the voltage-sensor site
  • a pore forming domain (H5) between the fifth and sixth transmembrane domains
  • a N glycosylation site
  • C-terminal region containing a cyclic-nucleotide-binding homology domain (CNBHD) and C-linker that couples the CNBHD to the pore
    • conjugated GlycoP
    mono polymer homomer , heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • potassium channel family
  • H (EAG) subfamily
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • pore forming (alpha) subunit of voltage-gated potassium channel
  • selectively involved in proliferation of distinct uterine cancer cells (Suzuki 2004)
  • forms the ion channel responsible for the rapidly acting delayed rectifier potassium current, I(Kr), and its blockade is a significant contributor to prolongation of the QT interval (Yoshida 2006)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    text prolactine secretion
    PATHWAY
    metabolism
    signaling
    a component
  • KCNH2, KCNH6
  • part of ERG channels control the excitability of medial vestibular nucleus neurones, their discharge regularity and probably their resonance properties (Pessia 2008)
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • cyclic nucleotide (cAMP)
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS